ARE YOU EXPERIENCING PANIC ATTACKS AFTER USING CANNABIS, MDMA, OR MUSHROOMS?

What is happening? Some substances like cannabis, MDMA (ecstasy), and psilocybin (magic mushrooms) affect brain chemistry, especially serotonin and perception pathways. While they may be used recreationally, they can also trigger intense anxiety, panic attacks, and feelings of depersonalization (feeling disconnected from yourself or reality).

Why does this occur?

• These substances can overstimulate the brain’s emotional and sensory systems

• They may alter perception, leading to fear, loss of control, or “unreal” sensations

• Mixing substances (or combining with psychiatric medications) increases risk

• Individual vulnerability (anxiety, trauma history, genetics) plays a major role

Common symptoms

• Sudden intense fear or panic

• Rapid heart rate, shortness of breath

• Dizziness or feeling faint

• Feeling detached from your body (depersonalization)

• Feeling like the world is unreal (derealization)

• Fear of dying or “going crazy”

These symptoms can occur during use or even after the substance wears off, and in some cases may persist.

Important clinical considerations

• Psychedelics and MDMA commonly cause acute anxiety and psychological distress, especially at higher doses or in uncontrolled settings

• Cannabis and hallucinogens are known triggers for panic and depersonalization episodes

• Combining serotonergic substances with medications (e.g., antidepressants, MAOIs) can increase risk of adverse reactions

• Co-use of multiple substances significantly increases unpredictability and harm

What helps?

• Stop substance use, especially during active symptoms

• Grounding techniques (focus on breathing, physical sensations)

• Safe, calm environment

• In some cases, medical or psychiatric treatment may be needed

  Start your recovery

  You deserve to feel grounded, safe, and in control again.

  Appointments available in-person and via telehealth.Bilingual care available (English & Spanish).